https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54124 Wed 28 Feb 2024 15:15:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27369 13), associated with low fibrinogen [median,<0.01g/L;IQR:<0.01-0.9g/L), low factor V levels [median,<5%;IQR:<5-4%], low factor VIII levels [median,40%;IQR:12-79%] and low factor X levels [median,48%; IQR:29-67%]. There were smaller reductions in factors II, IX and VII over time. All factors recovered over 48h post-antivenom. The median INR remained >3 at 6h post-antivenom but had reduced to <2, by 24h. The aPTT had also returned to close to normal (<50sec) at 24h. Factor VII, VIII and IX levels were unusually high pre-antivenom, median peak concentrations of 393%, 307% and 468% respectively. Pre-antivenom venom concentrations and the INR (r=0.20, p=0.02) and aPTT (r=0.19, p=0.03) were correlated (non-parametric Spearman analysis). Conclusions: Russell's viper coagulopathy results in prolonged aPTT, INR, low fibrinogen, factors V, VIII and X which recover over 48h. Severity of clotting abnormalities was associated with venom concentrations.]]> Wed 11 Apr 2018 11:40:46 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19519 Wed 11 Apr 2018 09:27:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55100 Wed 10 Apr 2024 08:45:11 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38373 80% of 18 samples as having short, medium or long telomeres compared with 33–72% using other methods.]]> Wed 01 Sep 2021 12:47:32 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36679 Thrombosis Research, Vol. 179, p. 28-30.]]> Tue 23 Jun 2020 15:03:42 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14861 Thu 28 Aug 2014 12:16:27 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50338 .8) for most normal cell types and did not require any manual reassignment. The AI digital differential was less reliable for abnormal blood films (r = .50-.87), but could be greatly improved by manual assessment of digital images for most cell types (r > .95) with the exception of immature granulocytes (r = .62). For blast identification, initial AI digital differentials showed 96% sensitivity and 25% specificity, which was improved to 99% and 84%, respectively, after manual digital review.Conclusions: The Techcyte platform allowed remote viewing and manual analysis of digitized slides that was comparable to microscopy. The AI software produced adequate WBC differentials for normal films and had high sensitivity for blast identification in malignant films.]]> Thu 20 Jul 2023 11:18:11 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9688 Sat 24 Mar 2018 08:39:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7335 Sat 24 Mar 2018 08:35:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1727 Sat 24 Mar 2018 08:27:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20929 n=41) and female (n=53). Platelet coagulation parameters including factors I, II, V, VII, VIII, IX, X, vWF:Ag and endogenous thrombin potential were measured at baseline and 4 weeks post supplementation with EPA-rich or DHA-rich oil capsules. Results: We have previously reported that platelet aggregation is specifically reduced by supplementation with EPA in males and DHA in females. This sex-specific effect was also observed for decreases in plasma levels of Factor II (-7.9±3.8%, P=.026), Factor V (-6.5±4.5%, P=.022) and vWF:Ag (-7.3±2.1%, P=.034) and was most pronounced in males supplemented with EPA. In contrast, DHA-mediated reduction in platelet aggregation in females was not accompanied by any significant changes in the coagulation parameters tested. Conclusion: Significant interactions between sex and specific LCn-3PUFA exist to reduce procoagulant activity differentially in males vs. females and could have profound effects on managing risk of thrombotic disease.]]> Sat 24 Mar 2018 08:06:03 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5432 Sat 24 Mar 2018 07:48:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22227 Sat 24 Mar 2018 07:17:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24131 In vitro clotting times were then used to calculate the effective concentration (EC₅₀) in each plasma for four snake venoms with different procoagulant toxins: Pseudonaja textilis, Daboia russelli, Echis carinatus and Calloselasma rhodostoma. Results: Compared to human, PT and aPTT were similar for rat, rabbit and pig, but double for cat and cow, while Guinea pig had similar aPTT but double PT. Fibrinogen and D-dimer levels were similar for all species. Human and rabbit plasmas had the lowest EC₅₀ for P. textilis (0.1 and 0.4 µg/ml), D. russelli (0.4 and 0.1 µg/ml), E. carinatus (0.6 and 0.1 µg/ml) venoms respectively, while cat plasma had the lowest EC₅₀ for C. rhodostoma (11 µg/ml) venom. Cow, rat, pig and Guinea pig plasmas were highly resistant to all four venoms with EC₅₀ 10-fold that of human. Conclusions: Different animal plasmas have varying susceptibility to procoagulant venoms, and excepting rabbits, animal models are not appropriate to test procoagulant activity. In vitro assays on human plasma should instead be adopted for this purpose.]]> Sat 24 Mar 2018 07:16:34 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50970 Mon 14 Aug 2023 15:19:54 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18589 Fri 13 Jul 2018 15:49:03 AEST ]]>